The coronavirus illness 2019 (COVID-19), caused by SARS-CoV-2, is a global health hazard. The recent detection of SARS-CoV-2 in the cerebrospinal fluid (CSF) and in frontal lobe sections from postmortem examination has confirmed the presence of the virus in neural tissue. This finding reveals a new direction in the search for a neurotherapeutic strategy in the COVID-19 patients with underlying diseases. It is important to consider the COVID-19 outbreak in a neuroinvasiveness context and the therapeutic use of high doses of melatonin, which may favorably modulate the immune response and neuroinflammation caused by SARS-CoV-2.
Dr. Rajesh Chawla
Critical Care
Senior Consultant, Institutes of Critical Care Respiratory and Sleep Medicine in Indraprastha Apollo Hospitals, New Delhi
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