Insulin initiation and titration can be challenging for several clinicians who are involved in the treatment of patients with type 2 diabetes. Moreover, in spite of the introduction of advanced insulin analogs and availability of improved insulin delivery devices, many patients with type 2 diabetes still have suboptimal glycemic control. In this issue of Diabetes News Nucleus, let us learn about insulin therapy for the management of diabetes patients - its initiation, titration and much more.