There are various mechanisms of SARS-CoV-2 infection and COVID-19 immunopathogenesis. Therapies inhibiting viral infection and regulation of dysfunctional immune responses may synergize to block pathologies at multiple steps. Immune dysfunction and disease severity in COVID-19 patients should be considered when developing and evaluating vaccines. Further research is needed on the host immune response to SARS-CoV-2, particularly the drivers of healthy versus dysfunctional outcomes. These will assist identify immunological correlates of protection and disease severity for optimal patient triage.
Dr. KK Aggarwal
President Heart Care Foundation of India and Group Editor in Chief MEDtalks
Dr. Rajesh Agrawala
Diabetologist in MEDI Care Hospital, Indore