According to the World Health Organization (WHO), we are rapidly approaching a 'post-antibiotic' era. The knowledge gap about antibiotic resistance and room for progress is evident and unified combating strategies to mitigate the inadvertent trends of resistance seem to be lacking. Doxycycline remains a valuable antimicrobial agent by virtue of its potent microbiological profile, anti-inflammatory and immunomodulatory activity, and practical advantages like cost-effectiveness and ease of availability. Indian clinicians may like to consider doxycycline optimally for effective infection care. This may help Indian healthcare system, in defying the massive battle against anti-microbial resistance.